(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide
SNC 80
CAS: 156727-74-1
Molecular Formula: C28H39N3O2
(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide - Names and Identifiers
(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide - Physico-chemical Properties
| Molecular Formula | C28H39N3O2 |
| Molar Mass | 449.63 |
| Density | 1.040 |
| Melting Point | 122-123°C |
| Boling Point | 564.8±50.0 °C(Predicted) |
| Solubility | DMSO: soluble |
| Appearance | solid |
| Color | off-white |
| pKa | 7.29±0.10(Predicted) |
| Storage Condition | Store at RT |
| Stability | Store in Freezer |
| In vitro study | SNC80 selectively activates μ-δ heteromer in HEK293 cells with an EC 50 of 52.8 nM. SNC80 exhibits substantially greater activity in cells coexpressing μ- and δ-opioid receptors than in cells either singly expressing δ-opioid receptors or coexpressing δ- and κ-opioid receptors. |
| In vivo study | SNC80 (10 mg/kg; intraperitoneal injection; once; C57BL6/J mice) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan. Animal Model: Male and female C57BL6/J mice (20-30g) injected with Sumatriptan Dosage: 10 mg/kg Administration: Intraperitoneal injection; once Result: Significantly attenuated allodynia. |
(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide - Risk and Safety
| WGK Germany | 3 |
(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide - Introduction
()-4-[(AR)-A-((2S,5R)-4-allyl-2, 5-dimethyl-1-piperazinyl)-3-Methoxybenzyl]-N,N-diethylbenzamide is a compound with the following properties:
1. Appearance: the common form is white powder.
2. Solubility: It is soluble in some organic solvents such as chloroform, dichloromethane and ethanol.
3. Melting Point: its melting point range between 135-140 ℃.
The main use of this compound is as a chiral ligand for catalytic asymmetric synthesis reactions. It plays an important role in the synthesis of drugs, pesticides and other bioactive molecules.
There are many methods for preparing this compound, but a common method is to react a suitable compound with benzoyl chloride in an organic solvent to generate the target compound.
Regarding safety information, due to the toxicity and danger of chemicals, you should be cautious when handling, understand and follow safe operation and protective measures. This compound may be harmful to health and may have an irritating and corrosive effect on the skin, eyes and mucous membranes. Wear appropriate personal protective equipment such as gloves, goggles and protective clothing during contact and handling. If any accidental exposure or ingestion occurs, seek medical advice immediately.
1. Appearance: the common form is white powder.
2. Solubility: It is soluble in some organic solvents such as chloroform, dichloromethane and ethanol.
3. Melting Point: its melting point range between 135-140 ℃.
The main use of this compound is as a chiral ligand for catalytic asymmetric synthesis reactions. It plays an important role in the synthesis of drugs, pesticides and other bioactive molecules.
There are many methods for preparing this compound, but a common method is to react a suitable compound with benzoyl chloride in an organic solvent to generate the target compound.
Regarding safety information, due to the toxicity and danger of chemicals, you should be cautious when handling, understand and follow safe operation and protective measures. This compound may be harmful to health and may have an irritating and corrosive effect on the skin, eyes and mucous membranes. Wear appropriate personal protective equipment such as gloves, goggles and protective clothing during contact and handling. If any accidental exposure or ingestion occurs, seek medical advice immediately.
Last Update：2024-04-09 21:04:16
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View History
(+)-4-[(αr)-α-((2s,5r)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-n,n-diethylbenzamide
2-(3-Fluoro-5-methylphenyl)cycloheptan-1-one
2,5-dimethoxy-N-(2-morpholinoethyl)benzenesulfonamide
(1S,2R)-2-{[4-(2,3-dihydro-1H-indol-1-ylsulfonyl)anilino]carbonyl}cyclohexanecarboxylic acid
METHYL 4-VINYLBENZOATE
4-[(4-Methoxyphenyl)methylene]-3-methylisoxazol-5(4H)-one
Ammonium Chloropalladite
1-[1,1'-biphenyl]-4-ylbenzo[f]quinoline
2-(5-AMINO-2-CHLOROPHENYL)-1,3-BENZOXAZOL-5-AMINE
Arbidol Impurity 77
2-(3-Fluoro-5-methylphenyl)cycloheptan-1-one
2,5-dimethoxy-N-(2-morpholinoethyl)benzenesulfonamide
(1S,2R)-2-{[4-(2,3-dihydro-1H-indol-1-ylsulfonyl)anilino]carbonyl}cyclohexanecarboxylic acid
METHYL 4-VINYLBENZOATE
4-[(4-Methoxyphenyl)methylene]-3-methylisoxazol-5(4H)-one
Ammonium Chloropalladite
1-[1,1'-biphenyl]-4-ylbenzo[f]quinoline
2-(5-AMINO-2-CHLOROPHENYL)-1,3-BENZOXAZOL-5-AMINE
Arbidol Impurity 77